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Product Usage Information

Storage

Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

Specificity / Sensitivity

PRAME (E7I1B) Rabbit mAb (Alexa Fluor^? 488 Conjugate) recognizes endogenous levels of total PRAME protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly163 of human PRAME protein.

Background

Cancer/testis antigens (CTAs) are a family of more than 100 proteins whose normal expression is largely restricted to immune privileged germ cells of the testis, ovary, and trophoblast cells of the placenta. Although most normal somatic tissues are void of CTA expression, due to epigenetic silencing of gene expression, their expression is upregulated in a wide variety of human solid and liquid tumors (1,2). As such, CTAs have garnered much attention as attractive targets for a variety of immunotherapy-based approaches to selectively attack tumors (3).

1. Caballero, O.L. and Chen, Y.T. (2009) Cancer Sci 100, 2014-21.
2. De Smet, C. et al. (1999) Mol Cell Biol 19, 7327-35.
3. Gjerstorff, M.F. et al. (2015) Oncotarget 6, 15772-87.