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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CYFIP1 (E6X1U) Rabbit mAb recognizes endogenous levels of total CYFIP1 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro527 of human CYFIP1 protein.

Background

Cytoplasmic FMR1-interacting protein 1 (CYFIP1) is a component of the CYFIP1/EIF4E/FMR1 complex which mediates translational repression by binding to the mRNA cap (1). CYFIP1 also plays a role in neuronal axonal growth dynamics by binding to the WAVE complex to regulate remodeling of actin filaments (2). Mutations in the gene encoding CYFIP1 has been linked to multiple neural development and psychiatric disorders, including autism spectrum disorder and schizophrenia (3-6). The specific mechanism by which CYFIP1, which is enriched in synapses, contributes to these neurological diseases is unknown, but may involve regulating the balance of synaptic excitation and inhibition to maintain neuronal circuit homeostasis during development and in mature brains (7).

1. Napoli, I. et al. (2008) Cell 134, 1042-54.
2. Chen, Z. et al. (2010) Nature 468, 533-8.
3. Toma, C. et al. (2014) Mol Psychiatry 19, 784-90.
4. Wang, J. et al. (2015) Ann Hum Genet 79, 329-40.
5. Tam, G.W. et al. (2010) Biochem Soc Trans 38, 445-51.
6. Yoon, K.J. et al. (2014) Cell Stem Cell 15, 79-91.
7. Davenport, E.C. et al. (2019) Cell Rep 26, 2037-51.e6.