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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Ly6k (E4K8Y) XP^? Rabbit mAb recognizes endogenous levels of total Ly6k protein.

Species Reactivity:

Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro70 of murine Ly6k protein.

Background

Cancer/testis antigens (CTAs) are a family of more than 100 proteins whose normal expression is largely restricted to immune privileged germ cells of the testis, ovary, and trophoblast cells of the placenta. Although most normal somatic tissues are void of CTA expression, due to epigenetic silencing of gene expression, their expression is upregulated in a wide variety of human solid and liquid tumors (1,2). As such, CTAs have garnered much attention as attractive targets for a variety of immunotherapy-based approaches to selectively attack tumors (3).

Ly6k is a member of the Ly6/urokinase type plasminogen activator receptor-like protein (uPAR)(LU) superfamily. It is expressed in testes where in interaction with another (uPAR)(LU) family member, TEX101, it is proposed to be necessary for the production of viable sperm (4). The human ortholog of this protein, LY6K, has been characterized to be a CTA. It is found to be upregulated in numerous types of cancer, including esophageal squamous cell carcinoma, bladder cancer, and breast cancer (5,6).

1. Caballero, O.L. and Chen, Y.T. (2009) Cancer Sci 100, 2014-21.
2. De Smet, C. et al. (1999) Mol Cell Biol 19, 7327-35.
3. Gjerstorff, M.F. et al. (2015) Oncotarget 6, 15772-87.
4. Endo, S. et al. (2016) Sci Rep 6, 23616.
5. Ishikawa, N. et al. (2007) Cancer Res 67, 11601-11.
6. Kono, K. et al. (2009) Cancer Sci 100, 1502-9.