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Calretinin (E7R6O) XP Rabbit mAb



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品    牌：CST/賽信通

貨    號：92635T

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Calretinin (E7R6O) XP ? Rabbit mAb
交貨周期:現(xiàn)貨 		20 μl 經(jīng)銷
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 北京敏泰元科技有限公司
庫存：20

  • 產(chǎn)品詳情

應(yīng)用：W, IHC-P, IF-F, IF-IC
Calretinin (29 kDa calbindin,calbindin 2) is a calcium-binding protein of the EF-hand family encoded by the CALB2 gene.It is differentially expressed from homologous family member calbindin-d28k in distinct neuronal populations of the retina, auditory system, and cerebellar granule cells (1,2), and acts as a marker for specific neuronal subsets of the subthalamic nucleus and the substantia nigra (3). Calretinin has been shown to play an important role in modulating neuronal excitability and the induction of long-term potentiation (1). Research has shown that, pathologically, calretinin is a selective marker for epithelial mesothelioma, making it a diagnostic tool to differentiate from adenocarcinomas (4).

Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 29
Source/Isotype Rabbit IgG

Application Key:

  • W-Western
  • IP-Immunoprecipitation
  • IHC-Immunohistochemistry
  • ChIP-Chromatin Immunoprecipitation
  • IF-Immunofluorescence
  • F-Flow Cytometry
  • E-P-ELISA-Peptide

Species Cross-Reactivity Key:

  • H-Human
  • M-Mouse
  • R-Rat
  • Hm-Hamster
  • Mk-Monkey
  • Vir-Virus
  • Mi-Mink
  • C-Chicken
  • Dm-D. melanogaster
  • X-Xenopus
  • Z-Zebrafish
  • B-Bovine
  • Dg-Dog
  • Pg-Pig
  • Sc-S. cerevisiae
  • Ce-C. elegans
  • Hr-Horse
  • All-All Species Expected

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunohistochemistry (Paraffin) 1:50 - 1:200
Immunofluorescence (Frozen) 1:100 - 1:400
Immunofluorescence (Immunocytochemistry) 1:100 - 1:400

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Calretinin (E7R6O) XP? Rabbit mAb recognizes endogenous levels of total Calretinin protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human Calretinin protein.

Background

Calretinin (29 kDa calbindin, calbindin 2) is a calcium-binding protein of the EF-hand family encoded by the CALB2 gene. It is differentially expressed from homologous family member calbindin-d28k in distinct neuronal populations of the retina, auditory system, and cerebellar granule cells (1,2), and acts as a marker for specific neuronal subsets of the subthalamic nucleus and the substantia nigra (3). Calretinin has been shown to play an important role in modulating neuronal excitability and the induction of long-term potentiation (1). Research has shown that, pathologically, calretinin is a selective marker for epithelial mesothelioma, making it a diagnostic tool to differentiate from adenocarcinomas (4).

  1. Camp, A.J. and Wijesinghe, R. (2009) Int J Biochem Cell Biol 41, 2118-21.
  2. Rogers, J.H. (1987) J Cell Biol 105, 1343-53.
  3. Fortin, M. and Parent, A. (1996) Brain Res 708, 201-4.
  4. Gotzos, V. et al. (1996) Pathol Res Pract 192, 137-47.

友情鏈接 :  中國科學(xué)院 國科控股 喀斯瑪控股有限公司 中科海外人才創(chuàng)業(yè)園

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