久久偷看各类wc女厕嘘嘘偷窃,国语对白农村老太婆bbw,久久婷婷五月综合色欧美,久久人与动人物a级毛片,久久久亚洲欧洲日产国码是av

Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CtBP1 (D2D6) Rabbit mAb recognizes endogenous levels of total CtBP1 protein.

Species Reactivity:

Human, Mouse, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CtBP1 protein.

Background

CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene activity through its intrinsic dehydrogenase activity (2,3) and by interacting with Polycomb Group (PcG) proteins during development (4). Along with its homologue, CtBP2, it acts as a transcriptional corepressor of zinc-finger homeodomain factor deltaEF1 to regulate a wide range of cellular processes through transrepression mechanisms (5). Through its direct interaction with PRDM16, CtBP1 has been shown to be involved in brown adipose tissue differentiation by mediating the repression of white fat genes and directing differentiation toward the brown fat gene program (6). CtBP1 also plays a role in lipid metabolic pathways and membrane fission by regulating the fission machinery operating Golgi tubular networks (7). CtBP1 has recently been shown to repress transcription of BRCA1 via a redox regulated mechanism (8). Furthermore, it is thought that downregulation of BRCA1 and E-cadherin in invasive ductal breast carcinoma correlates directly with activation of CtBP1 (9).

1. Schaeper, U. et al. (1995) Proc Natl Acad Sci U S A 92, 10467-71.
2. Balasubramanian, P. et al. (2003) FEBS Lett 537, 157-60.
3. Kumar, V. et al. (2002) Mol Cell 10, 857-69.
4. Sewalt, R.G. et al. (1999) Mol Cell Biol 19, 777-87.
5. Furusawa, T. et al. (1999) Mol Cell Biol 19, 8581-90.
6. Kajimura, S. et al. (2008) Genes Dev 22, 1397-409.
7. Cassens, U. et al. (1999) Transfus Med 9, 311-20.
8. Deng, Y. et al. (2010) Oncogene 29, 6603-8.
9. Deng, Y. et al. (2011) Mol Carcinog, Epub ahead of print.