久久偷看各类wc女厕嘘嘘偷窃,国语对白农村老太婆bbw,久久婷婷五月综合色欧美,久久人与动人物a级毛片,久久久亚洲欧洲日产国码是av

Product Usage Information

Storage

Supplied in 10 mM PBS containing 0.05% BSA and 0.05% sodium azide. Stable for 24 months when stored at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present, but will not interfere with antibody performance.

Specificity / Sensitivity

CD20 (L26) Mouse mAb recognizes endogenous levels of total CD20 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with human tonsil B cells.

Background

B-lymphocyte antigen CD20 (also known as MS4A1; Membrane-spanning 4-domains subfamily A member 1) is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation (1,2). It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse (1-3). Evidence suggests that CD20 is necessary for store operated calcium (SOC) entry, which leads to elevated cytoplasmic calcium levels required for B cell activation (4-5). Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases (6).

1. Stashenko, P. et al. (1980) J Immunol 125, 1678-85.
2. Tedder, T.F. et al. (1985) J Immunol 135, 973-9.
3. Tedder, T.F. et al. (1988) J Immunol 141, 4388-94.
4. Bubien, J.K. et al. (1993) J Cell Biol 121, 1121-32.
5. Li, H. et al. (2003) J Biol Chem 278, 42427-34.
6. Uchida, J. et al. (2004) J Exp Med 199, 1659-69.