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Product Usage Information

Storage

Supplied in 136 mM NaCl, 2.6 mM KCI, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg/ml BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

BCL6 (D4I2V) XP^? Rabbit mAb (Biotinylated) recognizes endogenous levels of total BCL6 protein. It is predicted to detect both human BCL6 isoform 1 and isoform 2.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein fragment spanning residues Asp210 through Thr409 of human BCL6 protein.

Background

Chromosomal translocations result in misregulation of the proto-oncogene BCL6 in patients with B cell-derived non-Hodgkin's lymphoma (1). The BCL6 gene is selectively expressed in mature B cells and encodes a nuclear phosphoprotein that belongs to the BTB/POZ zinc finger family of transcription factors (2,3). BCL6 protein can bind to target DNA sequences of Stat6 and, analogous to Stat6, modulate the expression of interleukin-4-induced genes (4). Furthermore, BCL6 restrains p53-dependent senescence, making BCL6-active tumors functionally p53-negative (5). The mitogen-activated protein kinases, Erk1 and Erk2, but not JNK, phosphorylate BCL6 at multiple sites. Phosphorylation of BCL6 at Ser333 and Ser343 results in degradation of BCL6 by the ubiquitin/proteasome pathway in B cells (6,7). In addition, BCL6 is acetylated and its transcriptional repressor function is inhibited by the transcriptional co-activator p300 (8).

1. Ye, B.H. et al. (1993) Science 262, 747-50.
2. Onizuka, T. et al. (1995) Blood 86, 28-37.
3. Zollman, S. et al. (1994) Proc Natl Acad Sci U S A 91, 10717-21.
4. Harris, M.B. et al. (1999) Mol Cell Biol 19, 7264-75.
5. Shvarts, A. et al. (2002) Genes Dev 16, 681-6.
6. Moriyama, M. et al. (1997) Oncogene 14, 2465-74.
7. Niu, H. et al. (1998) Genes Dev 12, 1953-61.
8. Bereshchenko, O.R. et al. (2002) Nat Genet 32, 606-13.