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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Calretinin (E7R6O) XP^? Rabbit mAb recognizes endogenous levels of total Calretinin protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human Calretinin protein.

Background

Calretinin (29 kDa calbindin, calbindin 2) is a calcium-binding protein of the EF-hand family encoded by the CALB2 gene. It is differentially expressed from homologous family member calbindin-d28k in distinct neuronal populations of the retina, auditory system, and cerebellar granule cells (1,2), and acts as a marker for specific neuronal subsets of the subthalamic nucleus and the substantia nigra (3). Calretinin has been shown to play an important role in modulating neuronal excitability and the induction of long-term potentiation (1). Research has shown that, pathologically, calretinin is a selective marker for epithelial mesothelioma, making it a diagnostic tool to differentiate from adenocarcinomas (4).

1. Camp, A.J. and Wijesinghe, R. (2009) Int J Biochem Cell Biol 41, 2118-21.
2. Rogers, J.H. (1987) J Cell Biol 105, 1343-53.
3. Fortin, M. and Parent, A. (1996) Brain Res 708, 201-4.
4. Gotzos, V. et al. (1996) Pathol Res Pract 192, 137-47.